For environments that have have to comply with 21 CFR part 11 (like pharma) it would really expand our ability to utilize Smartsheet if we could sign data entries made directly into Smartsheet. Ideally, we could have a column setting toggle to "apply signature and lock when entered" which would prompt the user to enter user/pass when they make an entry in that field*. Smartsheet's cell history is awesome, but it does not live up to the requirement that the user enter a password to e-sign. Docusign is not a good solution because it fails to be "contemporaneous" - we don't do the signing at the time/place of entry, and it also isn't displayed within the cell. The pdf is signed, but as an attachment it can easily be removed from the row. The applied signature would be linked to the cell itself. Ideally, there would also be a way to display that signature in another field if needed (probably a formula to show the signature from a target cell), so that it could be easily printed/displayed for records/auditors.
With functionality like this, Smartsheet could even be used as a laboratory notebook, opening up a vast new market.
*You would also need an "Unlock" option when a user right-clicks the cell, requiring user/pass to be entered anew.